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Article

Amiloride reduces stroke and renalinjury in stroke-prone hypertensive rats.

American journal of hypertension - 1 Apr 2003

Sepehrdad Reza, Chander Praveen N, Oruene Alafuro, Rosenfeld Louis, Levine Seymour, Stier Charles T

Abstract excerpt

BACKGROUND: We previously reported that the mineralocorticoid receptor antagonists spironolactone and eplerenone markedly reduce proteinuria and vascular injury in saline-drinking stroke-prone spontaneously hypertensive rats (SHRSP). Presently, we examined whether amiloride, an epithelial sodium channel blocker, would also protect against pathology in these rats. METHODS: In acute studies, saline-drinking SHRSP...

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Identifiers

PMID: 12670749
DOI: 10.1016/s0895-7061(03)00006-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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