Article
Nephroprotection by long-term ACE inhibition with ramipril in spontaneously hypertensive stroke prone rats.
Kidney international - 1 Dec 1998
Linz W, Becker R H, Schölkens B A, Wiemer G, Keil M, Langer K H
Abstract excerpt
BACKGROUND: The effect of life-long treatment with the ACE inhibitor ramipril on hypertension-induced histological changes in the kidney was tested in stroke-prone spontaneously hypertensive rats (SHR-SP). METHODS: One-month-old pre-hypertensive SHR-SP were randomized into three groups of 45 animals each, and exposed via drinking water for their lifetime to a dose of: 1 mg.kg-1.d-1 ramipril (antihypertensive...
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