Article
Nephroprotection by long-term ACE inhibition with ramipril in spontaneously hypertensive stroke prone rats.
Kidney international - 1 Dec 1998
Linz W, Becker R H, Schölkens B A, Wiemer G, Keil M, Langer K H
Abstract excerpt
BACKGROUND: The effect of life-long treatment with the ACE inhibitor ramipril on hypertension-induced histological changes in the kidney was tested in stroke-prone spontaneously hypertensive rats (SHR-SP). METHODS: One-month-old pre-hypertensive SHR-SP were randomized into three groups of 45 anim...
Topics
- Angiotensin-Converting Enzyme Inhibitors
- Animals
- Blood Vessels
- Cerebrovascular Disorders
- Dose-Response Relationship, Drug
- Genetic Predisposition to Disease
- Hypertension, Malignant
- Hypertrophy
- Kidney
- Male
- Necrosis
- Ramipril
- Rats
- Rats, Inbred SHR
- Time Factors