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Article

Predisposition of spontaneously hypertensive rats to develop renal injury during nitric oxide synthase inhibition.

European journal of pharmacology - 5 Jan 2001

Verhagen A M, Koomans H A, Joles J A

Abstract excerpt

Chronic nitric oxide (NO) synthase (NOS) inhibition results in renal injury. Hypertension is an important risk factor for renal injury. We studied the influence of preexistent hypertension on the sensitivity for renal injury induced by chronic NOS inhibition in rats. Spontaneously hypertensive (SHR) and normotensive Wistar-Kyoto (WKY) rats were treated with 3, 10, 30 and 100 mg/l Nomega-nitro-L-arginine (L-NNA)...

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Identifiers

PMID: 11137873
DOI: 10.1016/s0014-2999(00)00900-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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