Article
Dietary salt excess unmasks blunted aldosterone suppression and sodium retention in the stroke-prone phenotype of the spontaneously hypertensive rat.
Journal of hypertension - 1 Aug 1993
Volpe M, Rubattu S, Ganten D, Enea I, Russo R, Lembo G, Mirante A, Condorelli G, Trimarco B
Abstract excerpt
OBJECTIVE: The mechanisms underlying the accelerating effect of high salt intake on the development of vascular injury in the stroke-prone phenotype of spontaneously hypertensive rats (SHRSP) are still not clear. The aim of the present study was to determine whether young SHRSP can excrete a diet...
Topics
- Administration, Oral
- Aldosterone
- Animals
- Blood Pressure
- Body Weight
- Cerebrovascular Disorders
- Diet, Sodium-Restricted
- Heart Rate
- Hormones
- Male
- Mineralocorticoid Receptor Antagonists
- Phenotype
- Rats
- Rats, Inbred SHR
- Rats, Inbred WKY
- Sodium
- Sodium Chloride
- Urine