Article
Impaired cumulus mucification and female sterility in tumor necrosis factor-induced protein-6 deficient mice.
Development (Cambridge, England) - 1 May 2003
Fülöp Csaba, Szántó Sándor, Mukhopadhyay Durba, Bárdos Tamás, Kamath Rajesh V, Rugg Marylin S, Day Anthony J, Salustri Antonietta, Hascall Vincent C, Glant Tibor T, Mikecz Katalin
Abstract excerpt
Mucification of the cumulus layer around the oocyte is an obligatory process for female fertility. Tumor necrosis factor-induced protein-6 (TNFIP6 or TSG6) has been shown to be specifically expressed during this process. We have generated TNFIP6-deficient mice and tested the ability of their cumulus cells to undergo mucification. Cumulus cell-oocyte complexes fail to expand in TNFIP6-deficient female mice because...
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