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Functional Roles of Mouse Sperm Hyaluronidases, HYAL5 and SPAM1, in Fertilization1

16 Jul 2009

Abstract excerpt

Although sperm entry into the oocyte-cumulus complex and subsequent sperm penetration through the cumulus matrix to reach the oocyte zona pellucida are essential for mammalian fertilization, the molecular mechanism remains controversial. Previously, we have shown that mouse sperm lacking SPAM1 are capable of penetrating the cumulus matrix despite a delayed dispersal of cumulus cells. We also have identified...

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PMID: 19605784
DOI: 10.1095/biolreprod.109.078816

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Functional Roles of Mouse Sperm Hyaluronidases, HYAL5 and SPAM1, in Fertilization1PMID 19605784Read ↗

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