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Deletion ofAdam6inMus musculusleads to male subfertility and deficits in sperm ascent into the oviduct

4 Oct 2018

Abstract excerpt

The Adisintegrin and metalloprotease domain-containing (ADAM) family of proteins is involved in cell adhesion, migration, proteolysis, and signaling. Many ADAMs are required for reproduction; however, the role of Adam6 has remained largely unknown. In the course of humanizing the mouse immunoglobulin heavy chain (IgH) locus, we generated Adam6-deficient mice that demonstrate severe subfertility. We decided to...

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PMID: 30289441
DOI: 10.1093/biolre/ioy210

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