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Article

SPAM1/HYAL5 double deficiency in male mice leads to severe male subfertility caused by a cumulus‐oocyte complex penetration defect

31 Oct 2019

Abstract excerpt

The glycosylphosphatidylinositol‐anchored sperm hyaluronidases (Hyals), sperm adhesion molecule 1 (SPAM1) and HYAL5, have long been believed to assist in sperm penetration through the cumulus‐oocyte complex (COC), but their role in mammalian fertilization remains unclear. Previously, we have shown that mouse sperm devoid of either Spam1 or Hyal5 are still capable of penetrating the COC and that the loss of either...

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PMID: 31670981
DOI: 10.1096/fj.201900889rrr

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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