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Identification of a hyaluronidase, Hyal5, involved in penetration of mouse sperm through cumulus mass

5 Dec 2005

Abstract excerpt

A glycosylphosphatidylinositol (GPI)-anchored hyaluronidase, PH-20, on the sperm surface has long been believed to assist sperm penetration through the cumulus mass surrounding the eggs. However, mouse sperm lacking PH-20 were still capable of penetrating the cumulus mass despite a delayed dispersal of cumulus cells. Intriguingly, a 55-kDa hyaluronan-hydrolyzing protein was abundantly present in wild-type and...

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PMID: 16330764
DOI: 10.1073/pnas.0506825102

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

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Identification of a hyaluronidase, Hyal5, involved in penetration of mouse sperm through cumulus massPMID 16330764Read ↗

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Evolutionary, proteomic, and experimental investigations suggest the extracellular matrix of cumulus cells mediates fertilization outcomes†Semantic proximity Read ↗

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