Article
PTX3 plays a key role in the organization of the cumulus oophorus extracellular matrix and in in vivo fertilization.
Development (Cambridge, England) - 1 Apr 2004
Salustri Antonietta, Garlanda Cecilia, Hirsch Emilio, De Acetis Marika, Maccagno Alessia, Bottazzi Barbara, Doni Andrea, Bastone Antonio, Mantovani Giovanna, Beck Peccoz Paolo, Salvatori Giovanni, Mahoney David J, Day Anthony J, Siracusa Gregorio, Romani Luigina, Mantovani Alberto
Abstract excerpt
PTX3 is a prototypic long pentraxin that plays a non-redundant role in innate immunity against selected pathogens and in female fertility. Here, we report that the infertility of Ptx3(-/-) mice is associated with severe abnormalities of the cumulus oophorus and failure of in vivo, but not in vitro, oocyte fertilization. PTX3 is produced by mouse cumulus cells during cumulus expansion and localizes in the matrix....
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