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Evolutionary, proteomic, and experimental investigations suggest the extracellular matrix of cumulus cells mediates fertilization outcomes†

18 May 2021

Abstract excerpt

Studies of fertilization biology often focus on sperm and egg interactions. However, before gametes interact, mammalian sperm must pass through the cumulus layer; in mice, this consists of several thousand cells tightly glued together with hyaluronic acid and other proteins. To better understand the role of cumulus cells and their extracellular matrix, we perform proteomic experiments on cumulus oophorus...

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PMID: 34007991
DOI: 10.1093/biolre/ioab082

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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