Article
Peroxisome proliferator-activated receptor alpha activation modulates cellular redox status, represses nuclear factor-kappaB signaling, and reduces inflammatory cytokine production in aging.
The Journal of biological chemistry - 4 Dec 1998
Poynter M E, Daynes R A
Abstract excerpt
In aged mice, the redox-regulated transcription factor nuclear factor-kappaB (NF-kappaB) becomes constitutively active in many tissues, as well as in cells of the hematopoietic system. This oxidative stress-induced activity promotes the production of a number of pro-inflammatory cytokines, which...
Topics
- Acyl-CoA Oxidase
- Aging
- Animals
- Base Sequence
- Catalase
- Cytokines
- DNA Primers
- Dehydroepiandrosterone Sulfate
- Inflammation Mediators
- Lipid Peroxides
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- NF-kappa B
- Obesity
- Oxidation-Reduction
- Oxidoreductases
- Phenotype