Retroviral insertional mutagenesis: tagging cancer pathways.

doi:10.1016/s0065-230x(03)88304-5

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Article

Retroviral insertional mutagenesis: tagging cancer pathways.

Advances in cancer research - 1 Jan 2003

Mikkers Harald, Berns Anton

Abstract excerpt

Slow transforming retroviruses, such as the Moloney murine leukemia virus (M-MuLV), induce tumors upon infection of a host after a relatively long latency period. The underlying mechanism leading to cell transformation is the activation of proto-oncogenes or inactivation of tumor suppressor genes as a consequence of proviral insertions into the host genome. Cells carrying proviral insertions that confer a...

Topics

Animals
Cell Transformation, Neoplastic
Databases as Topic
Gene Transfer Techniques
Genetic Vectors
Humans
Lentivirus
Mice
Mice, Knockout
Models, Genetic
Moloney murine leukemia virus
Mutagenesis
Mutation
Neoplasm Transplantation
Neoplasms
Oncogenic Viruses
Proviruses
Retroviridae

Source

Open in PubMed

Identifiers

PMID: 12665053
DOI: 10.1016/s0065-230x(03)88304-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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