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Article

Retroviral insertional mutagenesis: tagging cancer pathways.

Advances in cancer research - 1 Jan 2003

Mikkers Harald, Berns Anton

Abstract excerpt

Slow transforming retroviruses, such as the Moloney murine leukemia virus (M-MuLV), induce tumors upon infection of a host after a relatively long latency period. The underlying mechanism leading to cell transformation is the activation of proto-oncogenes or inactivation of tumor suppressor genes as a consequence of proviral insertions into the host genome. Cells carrying proviral insertions that confer a...

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PMID: 12665053
DOI: 10.1016/s0065-230x(03)88304-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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