Article
Polymorphisms of the gene encoding the inflammatory cytokine interleukin-6 determine the magnitude of the increase in soluble interleukin-6 receptor levels in Alzheimer's disease. Results of a pilot study.
European archives of psychiatry and clinical neuroscience - 1 Feb 2003
Bagli Metin, Papassotiropoulos Andreas, Hampel Harald, Becker Karin, Jessen Frank, Bürger Katharina, Ptok U, Rao Marie Luise, Möller Hans-Jürgen, Maier Wolfgang, Heun Reinhard
Abstract excerpt
Interleukin-6 (IL-6) is a multifunctional cytokine involved in the pathogenesis of Alzheimer's disease (AD). The effects of IL-6 are mediated through a specific receptor complex made up of a ligand binding glycoprotein (gp80 or IL-6R) and a signal transducing glycoprotein (gp130). Conflicting results have been reported concerning altered IL-6 or soluble IL-6R (sIL-6R) levels in serum and CSF in AD. This study...
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