Article
Effect of IL-6 polymorphism on risk of Alzheimer disease: genotype-phenotype association study in Japanese cases.
American journal of medical genetics - 8 May 2002
Shibata Nobuto, Ohnuma Tohru, Takahashi Tadashi, Baba Hajime, Ishizuka Takuya, Ohtsuka Mieko, Ueki Akira, Nagao Masatsugu, Arai Heii
Abstract excerpt
Interleukin-6 (IL-6), an inflammatory cytokine might be involved in the pathophysiology of Alzheimer disease (AD); several studies have reported that the "C allele of IL-6 variable number of tandem repeat polymorphism" (IL-6vntr) delayed initial onset of AD and also decreased its risk per se. Another polymorphism, G/C allele of IL-6 gene promoter region (IL-6prom), is also a candidate because it has an influence...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.