Article
Sex-specific quantitative trait loci govern susceptibility to Theiler's murine encephalomyelitis virus-induced demyelination.
Genetics - 1 Mar 2003
Butterfield Russell J, Roper Randall J, Rhein Dominic M, Melvold Roger W, Haynes Lia, Ma Runlin Z, Doerge R W, Teuscher Cory
Abstract excerpt
Susceptibility to Theiler's murine encephalomyelitis virus-induced demyelination (TMEVD), a mouse model for multiple sclerosis (MS), is genetically controlled. Through a mouse-human comparative mapping approach, identification of candidate susceptibility loci for MS based on the location of TMEVD susceptibility loci may be possible. Composite interval mapping (CIM) identified quantitative trait loci (QTL)...
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