Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Allelic imbalance at intragenic markers of Tbx18 is a hallmark of murine osteosarcoma.

Carcinogenesis - 1 Mar 2003

Rosemann M, Kuosaite V, Nathrath M, Strom T M, Quintanilla-Martinez L, Richter T, Imai K, Atkinson M J

Abstract excerpt

We have recently identified a locus exhibiting a high frequency of allelic imbalance (AI) in both spontaneous human (HSA 6q14.1-15) and radiogenic murine (MMU9, 42 cM) osteosarcoma. Here we describe the fine mapping of the locus in osteosarcoma arising in (BALB/cxCBA) F(1) hybrid mice. These studies have allowed us to identify Tbx18, a member of the T-box transcriptional regulator gene family, as a candidate...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Neoplasms
Share to Hybrid Cells
Share to Introns

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Inbred BALB C

Share to Mice, Inbred CBA

Share to Osteosarcoma

Share to Sequence Tagged Sites

Share to T-Box Domain Proteins

Source

Identifiers

PMID: 12663494
DOI: 10.1093/carcin/24.3.371

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Allelic imbalance at intragenic markers of Tbx18 is a hallmark of murine osteosarcoma.PMID 12663494Read ↗

Two novel tumor suppressor gene loci on chromosome 6q and 15q in human osteosarcoma identified through comparative study of allelic imbalances in mouse and man.Semantic proximity Read ↗

Evidence for complex multigenic inheritance of radiation AML susceptibility in mice revealed using a surrogate phenotypic assay.Semantic proximity Read ↗

A comprehensive radiation hybrid map of bovine Chromosome 26 (BTA26): comparative chromosomal organization between HSA10q and BTA26 and BTA28.Semantic proximity Read ↗

Mouse Sox8 is located between, not within,the t-complex deletions t(w18) and t(h20) on chromosome 17.Semantic proximity Read ↗

A Rb1 promoter variant with reduced activity contributes to osteosarcoma susceptibility in irradiated mice.Semantic proximity Read ↗

Allelic loss mapping and physical delineation of a region harboring a thymic lymphoma suppressor gene on mouse chromosome 16.Semantic proximity Read ↗

Allelic loss at 10q26 in osteosarcoma in the region of the BUB3 and FGFR2 genes.Semantic proximity Read ↗

Four regions of allelic imbalance on 17q12-qter associated with high-grade breast tumors.Semantic proximity Read ↗

Identification and fine mapping of a region showing a high frequency of allelic imbalance on chromosome 16q23.2 that corresponds to a prostate cancer susceptibility locus.Semantic proximity Read ↗

Evidence for a Novel Osteosarcoma Tumor-Suppressor Gene in the Chromosome 18 Region Genetically Linked with Paget Disease of BoneSemantic proximity Read ↗

Differential effects of genes of the Rb1 signalling pathway on osteosarcoma incidence and latency in alpha-particle irradiated mice.Semantic proximity Read ↗

Illegitimate recombination leading to allelic loss and unbalanced translocation in p53-mutated human lymphoblastoid cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.