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Article

Two novel tumor suppressor gene loci on chromosome 6q and 15q in human osteosarcoma identified through comparative study of allelic imbalances in mouse and man.

Oncogene - 29 Aug 2002

Nathrath Michaela H, Kuosaite Virginija, Rosemann Michael, Kremer Marcus, Poremba Christopher, Wakana Shigeharu, Yanagi Masayuki, Nathrath Walter B J, Höfler Heinz, Imai Kenji, Atkinson Michael J

Abstract excerpt

We have performed a comparative study of allelic imbalances in human and murine osteosarcomas to identify genetic changes critical for osteosarcomagenesis. Two adjacent but discrete loci on mouse chromosome 9 were found to show high levels of allelic imbalance in radiation-induced osteosarcomas arising in (BALB/cxCBA/CA) F1 hybrid mice. The syntenic human chromosomal regions were investigated in 42 sporadic human...

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PMID: 12185601
DOI: 10.1038/sj.onc.1205764

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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