Article
CP2 binding to the promoter is essential for the enhanced transcription of globin genes in erythroid cells.
Molecules and cells - 28 Feb 2003
Chae Ji Hyung, Kim Chul Geun
Abstract excerpt
We have previously reported that the reduced level of CP2 suppresses the mouse alpha- and beta-globin gene expression and hemoglobin synthesis during terminal differentiation of mouse erythroleukemia (MEL) cells in vitro [Chae et al. (1999)]. As an extension of this study, we demonstrated that human alpha-, epsilon-, and gamma- globin genes were also suppressed by the reduced expression of CP2 in K562 cells. To...
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