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Article

Strand-biased defect in C/G transversions in hypermutating immunoglobulin genes in Rev1-deficient mice

13 Feb 2006

Abstract excerpt

Somatic hypermutation of Ig genes enables B cells of the germinal center to generate high-affinity immunoglobulin variants. Key intermediates in somatic hypermutation are deoxyuridine lesions, introduced by activation-induced cytidine deaminase. These lesions can be processed further to abasic sites by uracil DNA glycosylase. Mutagenic replication of deoxyuridine, or of its abasic derivative, by translesion...

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Identifiers

PMID: 16476771
DOI: 10.1084/jem.20052227

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Source receipt: pubmed, retrieved 7 Sept 2026.

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