Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PNA for one-base differentiating protection of DNA from nuclease and its use for SNPs detection.

Journal of the American Chemical Society - 2 Apr 2003

Komiyama Makoto, Ye Sheng, Liang Xingguo, Yamamoto Yoji, Tomita Takafumi, Zhou Jing-Min, Aburatani Hiroyuki

Abstract excerpt

By the combination of peptide nucleic acid (PNA) with single-stranded DNA specific nucleases, alteration of a single base to another in DNA has been detected with high accuracy. Only the DNAs in DNA/PNA duplexes involving a mismatch are efficiently hydrolyzed by these enzymes, whereas fully match...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apolipoproteins E
Share to Base Pair Mismatch
Share to DNA

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Electrophoresis, Polyacrylamide Gel

Share to Peptide Nucleic Acids

Share to Single-Strand Specific DNA and RNA Endonucleases

Share to Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

Share to Spectrophotometry, Ultraviolet

Source

Identifiers

PMID: 12656606
DOI: 10.1021/ja0295220

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12656606-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PNA for one-base differentiating protection of DNA from nuclease and its use for SNPs detection.PMID 12656606Read ↗

Simultaneous detection of multiple single nucleotide polymorphism by single-strand-specific nuclease and PNA probe.Semantic proximity Read ↗

Detection of single nucleotide polymorphisms by the combination of nuclease S1 and PNA.Semantic proximity Read ↗

Peptide nucleic acid-assisted colorimetric detection of single-nucleotide polymorphisms based on the intrinsic peroxidase-like activity of hemin-carbon nanotube nanocomposites.Semantic proximity Read ↗

Novel biosensing methodologies for improving the detection of single nucleotide polymorphism.Semantic proximity Read ↗

A novel method for SNP detection using a new duplex-specific nuclease from crab hepatopancreas.Semantic proximity Read ↗

PNA Clamping in Nucleic Acid Amplification Protocols to Detect Single Nucleotide Mutations Related to Cancer.Semantic proximity Read ↗

Conjugated polyelectrolyte amplified thiazole orange emission for label free sequence specific DNA detection with single nucleotide polymorphism selectivity.Semantic proximity Read ↗

Ion-exchange capture of labeled pyrrolidinyl peptide nucleic acids for DNA sequence determination.Semantic proximity Read ↗

Enhanced discrimination of single nucleotide polymorphism in genotyping by phosphorothioate proofreading allele-specific amplification.Semantic proximity Read ↗

Label-free genotyping of single-nucleotide polymorphisms for DNA and RNA targets using a cationic polythiophene derivate.Semantic proximity Read ↗

Detection of single-nucleotide polymorphisms using gold nanoparticles and single-strand-specific nucleases.Semantic proximity Read ↗

Homogeneous DNA-detection based on the non-enzymatic reactions promoted by target DNA.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.