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Article

Conjugated polyelectrolyte amplified thiazole orange emission for label free sequence specific DNA detection with single nucleotide polymorphism selectivity.

Analytical chemistry - 15 May 2009

Li Kai, Liu Bin

Abstract excerpt

We report a simple label-free method for sequence specific DNA detection using cationic conjugated polyelectrolyte (CCP) amplified thiazole orange (TO) emission as the signal. The discrimination of perfectly complementary DNA from a one-base mismatched sequence is accomplished by S1 nuclease digestion of the hybridized peptide nucleic acid (PNA)/DNA complexes. When the target DNA is complementary to the PNA...

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PMID: 19438268
DOI: 10.1021/ac9003985

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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