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Article

Interfering mutations provide in vivo evidence that Escherichia coli SecE functions in multimeric states.

Molecular genetics and genomics : MGG - 1 Mar 2003

Matsuo E, Mori H, Ito K

Abstract excerpt

SecY, SecE and SecG form a heterotrimer, which functions as a protein translocation channel in Escherichia coli. The cytosolic loop of SecE contains a segment that is conserved among different organisms. Here we show that mutational alterations in this segment not only inactivate the SecE function but confer dominant interfering properties on the altered SecE molecule. Such effects were especially evident in...

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Identifiers

PMID: 12655407
DOI: 10.1007/s00438-003-0803-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Interfering mutations provide in vivo evidence that Escherichia coli SecE functions in multimeric states.PMID 12655407Read ↗

Roles of the conserved cytoplasmic region and non-conserved carboxy-terminal region of SecE in Escherichia coli protein translocase.Semantic proximity Read ↗

A cytoplasmic domain is important for the formation of a SecY-SecE translocator complex.Semantic proximity Read ↗

Modeling the effects of prl mutations on the Escherichia coli SecY complex.Semantic proximity Read ↗

The carboxyl-terminal region of SecE interacts with SecY and is functional in the reconstitution of protein translocation activity in Escherichia coli.Semantic proximity Read ↗

Residues essential for the function of SecE, a membrane component of the Escherichia coli secretion apparatus, are located in a conserved cytoplasmic region.Semantic proximity Read ↗

A SecE mutation that modulates SecY-SecE translocase assembly, identified as a specific suppressor of SecY defects.Semantic proximity Read ↗

SecY and SecA interact to allow SecA insertion and protein translocation across the Escherichia coli plasma membrane.Semantic proximity Read ↗

SecY variants that interfere with Escherichia coli protein export in the presence of normal secY.Semantic proximity Read ↗

SecG is an auxiliary component of the protein export apparatus of Escherichia coli.Semantic proximity Read ↗

Protein translocation functions of Escherichia coli SecY: in vitro characterization of cold-sensitive secY mutants.Semantic proximity Read ↗

One of three transmembrane stretches is sufficient for the functioning of the SecE protein, a membrane component of the E. coli secretion machinery.Semantic proximity Read ↗

Importance of transmembrane segments in Escherichia coli SecY.Semantic proximity Read ↗

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