Article
Residues essential for the function of SecE, a membrane component of the Escherichia coli secretion apparatus, are located in a conserved cytoplasmic region.
Proceedings of the National Academy of Sciences of the United States of America - 29 Mar 1994
Murphy C K, Beckwith J
Abstract excerpt
Protein export in Escherichia coli is absolutely dependent on two integral membrane proteins, SecY and SecE. Previous deletion mutagenesis of the secE gene showed that only the third of three membrane-spanning segments and a portion of the second cytoplasmic region are necessary for its function...
Topics
- Amino Acid Sequence
- Bacterial Proteins
- Base Sequence
- Conserved Sequence
- Cytoplasm
- Escherichia coli
- Escherichia coli Proteins
- Gene Deletion
- Genetic Complementation Test
- Molecular Sequence Data
- Mutation
- Protein Structure, Secondary
- SEC Translocation Channels
- Sequence Homology, Amino Acid