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Article

Residues essential for the function of SecE, a membrane component of the Escherichia coli secretion apparatus, are located in a conserved cytoplasmic region.

Proceedings of the National Academy of Sciences of the United States of America - 29 Mar 1994

Murphy C K, Beckwith J

Abstract excerpt

Protein export in Escherichia coli is absolutely dependent on two integral membrane proteins, SecY and SecE. Previous deletion mutagenesis of the secE gene showed that only the third of three membrane-spanning segments and a portion of the second cytoplasmic region are necessary for its function in protein export. Here we further define the residues important for SecE function. Alignment of the SecE homologues of...

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Identifiers

PMID: 8146153
DOI: 10.1073/pnas.91.7.2557
PMCID: PMC43408

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Residues essential for the function of SecE, a membrane component of the Escherichia coli secretion apparatus, are located in a conserved cytoplasmic region.PMID 8146153Read ↗

Roles of the conserved cytoplasmic region and non-conserved carboxy-terminal region of SecE in Escherichia coli protein translocase.Semantic proximity Read ↗

One of three transmembrane stretches is sufficient for the functioning of the SecE protein, a membrane component of the E. coli secretion machinery.Semantic proximity Read ↗

Roles of the C-terminal end of SecY in protein translocation and viability of Escherichia coli.Semantic proximity Read ↗

Importance of transmembrane segments in Escherichia coli SecY.Semantic proximity Read ↗

A SecE mutation that modulates SecY-SecE translocase assembly, identified as a specific suppressor of SecY defects.Semantic proximity Read ↗

Mutational analysis of transmembrane regions 3 and 4 of SecY, a central component of protein translocase.Semantic proximity Read ↗

Functional identification of the product of the Bacillus subtilis yvaL gene as a SecG homologue.Semantic proximity Read ↗

The carboxyl-terminal region of SecE interacts with SecY and is functional in the reconstitution of protein translocation activity in Escherichia coli.Semantic proximity Read ↗

Protein translocation functions of Escherichia coli SecY: in vitro characterization of cold-sensitive secY mutants.Semantic proximity Read ↗

The SecY translocation complex: convergence of genetics and structure.Semantic proximity Read ↗

Interfering mutations provide in vivo evidence that Escherichia coli SecE functions in multimeric states.Semantic proximity Read ↗

A cytoplasmic domain is important for the formation of a SecY-SecE translocator complex.Semantic proximity Read ↗

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