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Article

Major histocompatibility complex heterozygote superiority during coinfection.

Infection and immunity - 1 Apr 2003

McClelland Erin E, Penn Dustin J, Potts Wayne K

Abstract excerpt

Genes of the major histocompatibility complex (MHC) play a critical role in immune recognition, and many alleles confer susceptibility to infectious and autoimmune diseases. How these deleterious alleles persist in populations is controversial. One hypothesis postulates that MHC heterozygote superiority emerges over multiple infections because MHC-mediated resistance is generally dominant and many allele-specific...

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Identifiers

PMID: 12654829
DOI: 10.1128/IAI.71.4.2079-2086.2003
PMCID: PMC152037

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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