Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effect of human leukocyte antigen heterozygosity on infectious disease outcome: the need for allele-specific measures.

BMC medical genetics - 24 Jan 2003

Lipsitch Marc, Bergstrom Carl T, Antia Rustom

Abstract excerpt

BACKGROUND: Doherty and Zinkernagel, who discovered that antigen presentation is restricted by the major histocompatibility complex (MHC, called HLA in humans), hypothesized that individuals heterozygous at particular MHC loci might be more resistant to particular infectious diseases than the corresponding homozygotes because heterozygotes could present a wider repertoire of antigens. The superiority of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Communicable Diseases
Share to Confounding Factors, Epidemiologic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, Dominant

Share to Genes, Recessive

Share to Genetic Carrier Screening

Share to HLA Antigens

Share to Immunity, Innate

Share to Models, Immunological

Source

Open in PubMed Open full text

Identifiers

PMID: 12542841
DOI: 10.1186/1471-2350-4-2
PMCID: PMC149356

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effect of human leukocyte antigen heterozygosity on infectious disease outcome: the need for allele-specific measures.PMID 12542841Read ↗

HLA Heterozygote Advantage against HIV-1 Is Driven by Quantitative and Qualitative Differences in HLA Allele-Specific Peptide Presentation.Semantic proximity Read ↗

Evidence for human leukocyte antigen heterozygote advantage against hepatitis C virus infection.Semantic proximity Read ↗

A limit to the divergent allele advantage model supported by variable pathogen recognition across HLA-DRB1 allele lineages.Semantic proximity Read ↗

HLA and HIV-1: heterozygote advantage and B*35-Cw*04 disadvantage.Semantic proximity Read ↗

Human leukocyte antigen class II gene diversity tunes antibody repertoires to common pathogensSemantic proximity Read ↗

Common HLA alleles associated with health, but not with facial attractiveness.Semantic proximity Read ↗

Major histocompatibility complex heterozygote superiority during coinfection.Semantic proximity Read ↗

Parasites and individual major histocompatibility complex diversity--an optimal choice?Semantic proximity Read ↗

Divergent Allele Advantage at Human MHC Genes: Signatures of Past and Ongoing Selection.Semantic proximity Read ↗

An asymmetric model of heterozygote advantage at major histocompatibility complex genes: degenerate pathogen recognition and intersection advantage.Semantic proximity Read ↗

Impact of HLA class I functional divergence on HIV control.Semantic proximity Read ↗

The influence of HLA class I alleles and heterozygosity on the outcome of human T cell lymphotropic virus type I infection.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.