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Article

Experimental viral evolution to specific host MHC genotypes reveals fitness and virulence trade-offs in alternative MHC types.

Proceedings of the National Academy of Sciences of the United States of America - 28 Feb 2012

Kubinak Jason L, Ruff James S, Hyzer Cornelius Whitney, Slev Patricia R, Potts Wayne K

Abstract excerpt

The unprecedented genetic diversity found at vertebrate MHC (major histocompatibility complex) loci influences susceptibility to most infectious and autoimmune diseases. The evolutionary explanation for how these polymorphisms are maintained has been controversial. One leading explanation, antagonistic coevolution (also known as the Red Queen), postulates a never-ending molecular arms race where pathogens evolve...

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Identifiers

PMID: 22323587
DOI: 10.1073/pnas.1112633109
PMCID: PMC3295311

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