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Article

HDAC6 Deacetylates Ku70 and Regulates Ku70-Bax Binding in Neuroblastoma

1 Aug 2011

Abstract excerpt

Ku70 was first characterized as a nuclear factor that binds DNA double-strand breaks in nonhomolog end-joining DNA repair. However, recent studies have shown that Ku70 is also found in the cytoplasm and binds Bax, preventing Bax-induced cell death. We have shown that, in neuroblastoma cells, the binding between Ku70 and Bax depends on the acetylation status of Ku70, such that, when Ku70 is acetylated, Bax is...

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PMID: 21847364
DOI: 10.1593/neo.11558

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HDAC6 Deacetylates Ku70 and Regulates Ku70-Bax Binding in NeuroblastomaPMID 21847364Read ↗

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