Article
Five mutations in the GABA A alpha6 gene 5' flanking region are associated with a reduced basal and ethanol-induced alpha6 upregulation in mutated Sardinian alcohol non-preferring rats.
Brain research. Molecular brain research - 13 Jun 2005
Saba Luisella, Porcella Anna, Sanna Angela, Congeddu Elena, Marziliano Nicola, Mongeau Raymond, Grayson Dennis, Pani Luca
Abstract excerpt
The presence of four nucleotide changes and a three base-pair deletion in the GABA A alpha6-subunit promoter is described in Sardinian alcohol non-preferring rats, selectively bred for their ethanol aversion. These mutations are associated with the R100Q alpha6 intragenic mutation that was previously characterized in the same animals. The possibility that these mutated nucleotides alter the ethanol-induced...
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