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Article

HLA-A3 supermotif defined by quantitative structure-activity relationship analysis.

Protein engineering - 1 Jan 2003

Guan Pingping, Doytchinova Irini A, Flower Darren R

Abstract excerpt

Activation of a cytotoxic T cell requires specific binding of antigenic peptides to major histocompatibility complex (MHC) molecules. This paper reports a study of peptides binding to members of the HLA-A3 superfamily using a recently developed 2D-QSAR method, called the additive method. Four alleles with high phenotype frequency were included in the study: A*0301, A*1101, A*3101 and A*6801. The influence of each...

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Identifiers

PMID: 12646688
DOI: 10.1093/proeng/gzg005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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