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Article

In silico identification of supertypes for class II MHCs.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jun 2005

Doytchinova Irini A, Flower Darren R

Abstract excerpt

The development of epitope-based vaccines, which have wide population coverage, is greatly complicated by MHC polymorphism. The grouping of alleles into supertypes, on the basis of common structural and functional features, addresses this problem directly. In the present study we applied a combined bioinformatics approach, based on analysis of both protein sequence and structure, to identify similarities in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15905552
DOI: 10.4049/jimmunol.174.11.7085

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