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Article

In silico grouping of peptide/HLA class I complexes using structural interaction characteristics.

Bioinformatics (Oxford, England) - 15 Jan 2007

Tong Joo Chuan, Tan Tin Wee, Ranganathan Shoba

Abstract excerpt

MOTIVATION: Classification of human leukocyte antigen (HLA) proteins into supertypes underpins the development of epitope-based vaccines with wide population coverage. Current methods for HLA supertype definition, based on common structural features of HLA proteins and/or their functional binding specificities, leave structural interaction characteristics among different HLA supertypes with antigenic peptides...

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Identifiers

PMID: 17090577
DOI: 10.1093/bioinformatics/btl563

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