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Article

Mutation of Y179 on phospholipase D2 (PLD2) upregulates DNA synthesis in a PI3K-and Akt-dependent manner.

Cellular signalling - 1 Jan 2008

Di Fulvio Mauricio, Frondorf Kathleen, Gomez-Cambronero Julian

Abstract excerpt

Phospholipase D2 (PLD2), one of the two mammalian members of the PLD family, has been implicated in cell proliferation, transformation, tumor progression and survival. However, as precise mechanistic details are still unknown, we investigated here if the PLD2 isoform would signal through the PI3K/AKT pathway. Transient expression of PLD2 in COS7 cells with either the WT or with a Y179F mutant, resulted in an...

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Source

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Identifiers

PMID: 18006275
DOI: 10.1016/j.cellsig.2007.10.009
PMCID: PMC2276604

Genes

PLD2
PCNA

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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