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Article

Involvement of phospholipase D2 in lysophosphatidate-induced transactivation of platelet-derived growth factor receptor-beta in human bronchial epithelial cells.

The Journal of biological chemistry - 10 Oct 2003

Wang Lixin, Cummings Rhett, Zhao Yutong, Kazlauskas Andrius, Sham James K S, Morris Andrew, Georas Steve, Brindley David N, Natarajan Viswanathan

Abstract excerpt

Lysophosphatidate (LPA) mediates multiple cellular responses via heterotrimeric G protein coupled LPA-1, LPA-2, and LPA-3 receptors. Many G protein-coupled receptors stimulate ERK following tyrosine phosphorylation of growth factor receptors; however, the mechanism(s) of transactivation of recept...

Read the complete abstract on PubMed

Topics

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Share to Bronchi
Share to DNA, Complementary

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epithelial Cells

Share to Lysophospholipids

Share to Phospholipase D

Share to Receptor, Platelet-Derived Growth Factor beta

Share to Receptors, G-Protein-Coupled

Share to Transcriptional Activation

Source

Identifiers

PMID: 12890682
DOI: 10.1074/jbc.M302896200

Genes

LPA
PLD2
PLD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12890682-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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Involvement of phospholipase D2 in lysophosphatidate-induced transactivation of platelet-derived growth factor receptor-beta in human bronchial epithelial cells.PMID 12890682Read ↗

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