Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The transcription factors Slug (SNAI2) and Snail (SNAI1) regulate phospholipase D (PLD) promoter in opposite ways towards cancer cell invasion

19 Dec 2015

Abstract excerpt

Slug (SNAI2) and Snail (SNAI1) are master regulatory transcription factors for organogenesis and wound healing, and they are involved in the epithelial to mesenchymal transition (EMT) of cancer cells. We found that the activity of phospholipase D isoform 2 (PLD2) is highly increased in cancers with larger size and poor prognosis (MDA-MB-231 versus MCF-7 cells), so we determined if Snail or Slug were responsible...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Cancer-related Molecular Pathways
Share to Epigenetics and DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26781944
DOI: 10.1016/j.molonc.2015.12.006

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The transcription factors Slug (SNAI2) and Snail (SNAI1) regulate phospholipase D (PLD) promoter in opposite ways towards cancer cell invasionPMID 26781944Read ↗

Functional Regulation of Phospholipase D Expression in Cancer and InflammationSemantic proximity Read ↗

Down-regulation of MicroRNAs (MiRs) 203, 887, 3619 and 182 Prevents Vimentin-triggered, Phospholipase D (PLD)-mediated Cancer Cell Invasion.Semantic proximity Read ↗

PLCD3 inhibits apoptosis and promotes proliferation, invasion and migration in gastric cancerSemantic proximity Read ↗

FOXD1 promotes proliferation, migration and epithelial-mesenchymal transformation of esophageal squamous cell carcinoma by targeting SNAI1Semantic proximity Read ↗

A new signaling pathway (JAK-Fes-phospholipase D) that is enhanced in highly proliferative breast cancer cells.Semantic proximity Read ↗

Protein kinase D activity is a risk biomarker in prostate cancer that drives cell invasion by a Snail/ERK dependent mechanismSemantic proximity Read ↗

<scp>KMT2D</scp> links <scp>TGF</scp> ‐β signaling to noncanonical activin pathway and regulates pancreatic cancer cell plasticitySemantic proximity Read ↗

DEDD, a novel tumor repressor, reverses epithelial-mesenchymal transition by activating selective autophagySemantic proximity Read ↗

Positive Feedback Regulation between Phospholipase D and Wnt Signaling Promotes Wnt-Driven Anchorage-Independent Growth of Colorectal Cancer CellsSemantic proximity Read ↗

KMT2D links TGF-β Signalling to Non-Canonical Activin Pathway and Regulates Pancreatic Cancer Cell PlasticitySemantic proximity Read ↗

A comprehensive model that explains the regulation of phospholipase D2 activity by phosphorylation-dephosphorylation.Semantic proximity Read ↗

Phosphatidylinositol (3,4,5)-trisphosphate specifically interacts with the phox homology domain of phospholipase D1 and stimulates its activity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.