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Article

Transforming growth factor-beta induces secretion of activated ADAMTS-2. A procollagen III N-proteinase.

The Journal of biological chemistry - 23 May 2003

Wang Wei-Man, Lee Seungbok, Steiglitz Barry M, Scott Ian C, Lebares Carter C, Allen M Leah, Brenner Mitchell C, Takahara Kazuhiko, Greenspan Daniel S

Abstract excerpt

The metalloproteinase ADAMTS-2 has procollagen I N-proteinase activity capable of cleaving procollagens I and II N-propeptides in vitro, whereas mutations in the ADAMTS-2 gene in dermatosparaxis and Ehlers-Danlos syndrome VIIC show this enzyme to be responsible in vivo for most biosynthetic processing of procollagen I N-propeptides in skin. Yet despite its important role in the regulation of collagen deposition,...

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PMID: 12646579
DOI: 10.1074/jbc.M300767200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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