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Article

Metallothionein-dependent up-regulation of TGF-β2 participates in the remodelling of the myxomatous mitral valve

16 Dec 2011

Abstract excerpt

AIMS: Although an excessive extracellular matrix remodelling has been well described in myxomatous mitral valve (MMV), the underlying pathogenic mechanisms remain largely unknown. Our goal was to identify dysregulated genes in human MMV and then to evaluate their functional role in the progression of the disease. METHODS AND RESULTS: Dysregulated genes were investigated by transcriptomic, immunohistochemistry,...

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PMID: 22180604
DOI: 10.1093/cvr/cvr337

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