Article
Gene expression of detoxifying enzymes in AhR and Nrf2 compound null mutant mouse.
Biochemical and biophysical research communications - 28 Mar 2003
Noda Shuhei, Harada Nobuhiko, Hida Azumi, Fujii-Kuriyama Yoshiaki, Motohashi Hozumi, Yamamoto Masayuki
Abstract excerpt
The arylhydrocarbon receptor (AhR) regulates the expression of cytochrome P450 (CYP)-1 gene family members which catalyze xenobiotic Phase I metabolism, while Nrf2 exerts the concerted regulation of Phase II enzyme genes. We generated AhR and Nrf2 compound null mutant mice to examine the integrated function of AhR- and Nrf2-regulated enzymes in detoxification. Furthermore, we used this mouse model, by...
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