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Article

Impact of Cyp1a2 or Ahr gene knockout in mice: implications for biomonitoring studies.

Toxicology letters - 10 Apr 2006

Talaska Glenn, Ginsburg David, LaDow Kathy, Puga Alvaro, Dalton Timothy, Warshawsky David

Abstract excerpt

UNLABELLED: Studies of the impact of phase 1 enzyme polymorphisms on genetic damage have yielded mixed results. We studied how genetic damage would be altered when specific genes were ablated under low dose conditions. METHODS: Knockouts (KO) were generated from c57bl6/J mice with mutations in Cyp1a2 or Ahr receptor that eliminated gene product function. Animals were treated topically with either 4-aminobiphenyl...

Topics

Aminobiphenyl Compounds
Animals
Basic Helix-Loop-Helix Transcription Factors
Benzo(a)pyrene
Carbazoles
Carcinogens
Cytochrome P-450 CYP1A2
DNA Adducts
Environmental Monitoring
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Variation

Liver

Lung

Mice

Mice, Inbred C57BL

Mice, Knockout

Polychlorinated Dibenzodioxins

Receptors, Aryl Hydrocarbon

Source

Identifiers

PMID: 16256281
DOI: 10.1016/j.toxlet.2005.09.020

Genes

AHR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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