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Article

Increased susceptibility of Nrf2-null mice to 1-bromopropane-induced hepatotoxicity.

Toxicological sciences : an official journal of the Society of Toxicology - 1 Jun 2010

Liu Fang, Ichihara Sahoko, Valentine William M, Itoh Ken, Yamamoto Masayuki, Sheik Mohideen Sahabudeen, Kitoh Junzoh, Ichihara Gaku

Abstract excerpt

1-Bromopropane (1-BP) was introduced as an alternative to ozone-depleting solvents. However, it was found to exhibit neurotoxicity, reproductive toxicity, and hepatotoxicity in rodents and neurotoxicity in human. However, the mechanisms underlying the toxicities of 1-BP remain elusive. The present study investigated the role of oxidative stress in 1-BP-induced hepatotoxicity using nuclear factor erythroid...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20211940
DOI: 10.1093/toxsci/kfq075

Genes

NQO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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