Dominant lethal mutations induced in mouse spermatogonia by mechlorethamine, procarbazine and vincristine administered in 2-drug and 3-drug combinations.

Abstract excerpt

Male mice were treated with mechlorethamine (2.0 mg/kg), procarbazine (100 mg/kg) and vincristine (0.67 mg/kg) alone, or in 2-drug and 3-drug combinations. 5 weeks later and continuing for 5-8 weeks, embryos fertilized by spermatozoa that were derived from drug-treated spermatogonia were evaluated for drug-induced dominant lethal mutations. Significant mutagenesis was detected for mechlorethamine alone, for...

Topics

• Animals
• Antineoplastic Combined Chemotherapy Protocols
• Drug Interactions
• Fertilization
• Genes, Dominant
• Genes, Lethal
• Male
• Mechlorethamine
• Mice
• Mutation
• Prednisone