Article
Drosophila paramyosin is important for myoblast fusion and essential for myofibril formation.
The Journal of cell biology - 17 Mar 2003
Liu Hongjun, Mardahl-Dumesnil Michelle, Sweeney Sean T, O'Kane Cahir J, Bernstein Sanford I
Abstract excerpt
Paramyosin is a major structural protein of thick filaments in invertebrate muscles. Coiled-coil dimers of paramyosin form a paracrystalline core of these filaments, and the motor protein myosin is arranged on the core surface. To investigate the function of paramyosin in myofibril assembly and muscle contraction, we functionally disrupted the Drosophila melanogaster paramyosin gene by mobilizing a P element...
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