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Article

The Wiskott-Aldrich syndrome protein (WASP) is essential for myoblast fusion in Drosophila.

Developmental biology - 15 Apr 2007

Schäfer Gritt, Weber Susanne, Holz Anne, Bogdan Sven, Schumacher Sabine, Müller Arno, Renkawitz-Pohl Renate, Onel Susanne-Filiz

Abstract excerpt

In higher organisms, mononucleated myoblasts fuse to form multinucleated myotubes. During this process, myoblasts undergo specific changes in cell morphology and cytoarchitecture. Previously, we have shown that the actin regulator Kette (Hem-2/Nap-1) is essential for myoblast fusion. In this study, we describe the role of the evolutionary conserved Wiskott-Aldrich syndrome protein that serves as a regulator for...

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Identifiers

PMID: 17306790
DOI: 10.1016/j.ydbio.2007.01.015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Wiskott-Aldrich syndrome protein (WASP) is essential for myoblast fusion in Drosophila.PMID 17306790Read ↗

Drosophila Kette coordinates myoblast junction dissolution and the ratio of Scar-to-WASp during myoblast fusion.Semantic proximity Read ↗

SCAR/WAVE and Arp2/3 are crucial for cytoskeletal remodeling at the site of myoblast fusion.Semantic proximity Read ↗

kette and blown fuse interact genetically during the second fusion step of myogenesis in Drosophila.Semantic proximity Read ↗

The actin nucleator WASp is required for myoblast fusion during adult Drosophila myogenesis.Semantic proximity Read ↗

A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.Semantic proximity Read ↗

Analysis of the cell adhesion molecule sticks-and-stones reveals multiple redundant functional domains, protein-interaction motifs and phosphorylated tyrosines that direct myoblast fusion in Drosophila melanogaster.Semantic proximity Read ↗

Kette regulates actin dynamics and genetically interacts with Wave and Wasp.Semantic proximity Read ↗

Drosophila dumbfounded: a myoblast attractant essential for fusion.Semantic proximity Read ↗

The SCAR and WASp nucleation-promoting factors act sequentially to mediate Drosophila myoblast fusion.Semantic proximity Read ↗

Signalling to actin assembly via the WASP (Wiskott-Aldrich syndrome protein)-family proteins and the Arp2/3 complexSemantic proximity Read ↗

KAR3, a kinesin-related gene required for yeast nuclear fusion.Semantic proximity Read ↗

Myomaker is required for the fusion of fast-twitch myocytes in the zebrafish embryo.Semantic proximity Read ↗

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