The Wiskott-Aldrich syndrome protein (WASP) is essential for myoblast fusion in Drosophila.

doi:10.1016/j.ydbio.2007.01.015

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Article

The Wiskott-Aldrich syndrome protein (WASP) is essential for myoblast fusion in Drosophila.

Developmental biology - 15 Apr 2007

Schäfer Gritt, Weber Susanne, Holz Anne, Bogdan Sven, Schumacher Sabine, Müller Arno, Renkawitz-Pohl Renate, Onel Susanne-Filiz

Abstract excerpt

In higher organisms, mononucleated myoblasts fuse to form multinucleated myotubes. During this process, myoblasts undergo specific changes in cell morphology and cytoarchitecture. Previously, we have shown that the actin regulator Kette (Hem-2/Nap-1) is essential for myoblast fusion. In this study, we describe the role of the evolutionary conserved Wiskott-Aldrich syndrome protein that serves as a regulator for...

Topics

Alleles
Animals
Cell Fusion
Drosophila
Drosophila Proteins
Microfilament Proteins
Mutation
Myoblasts
Wiskott-Aldrich Syndrome Protein

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Open in PubMed

Identifiers

PMID: 17306790
DOI: 10.1016/j.ydbio.2007.01.015

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