Article
Impaired embryonic motility in dusp27 mutants reveals a developmental defect in myofibril structure.
Disease models & mechanisms - 1 Feb 2014
Fero Kandice, Bergeron Sadie A, Horstick Eric J, Codore Hiba, Li Grace H, Ono Fumihito, Dowling James J, Burgess Harold A
Abstract excerpt
An essential step in muscle fiber maturation is the assembly of highly ordered myofibrils that are required for contraction. Much remains unknown about the molecular mechanisms governing the formation of the contractile apparatus. We identified an early embryonic motility mutant in zebrafish caused by integration of a transgene into the pseudophosphatase dual specificity phosphatase 27 (dusp27) gene. dusp27...
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