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Article

Repressor activity of Headless/Tcf3 is essential for vertebrate head formation.

Nature - 19 Oct 2000

Kim C H, Oda T, Itoh M, Jiang D, Artinger K B, Chandrasekharappa S C, Driever W, Chitnis A B

Abstract excerpt

The vertebrate organizer can induce a complete body axis when transplanted to the ventral side of a host embryo by virtue of its distinct head and trunk inducing properties. Wingless/Wnt antagonists secreted by the organizer have been identified as head inducers. Their ectopic expression can promote head formation, whereas ectopic activation of Wnt signalling during early gastrulation blocks head formation. These...

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Identifiers

PMID: 11057671
DOI: 10.1038/35038097
PMCID: PMC4018833

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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