Article
The calcium-binding proteins MRP8 and MRP14 form a membrane-associated heterodimer in a subset of monocytes/macrophages present in acute but absent in chronic inflammatory lesions.
European journal of immunology - 1 Jul 1992
Bhardwaj R S, Zotz C, Zwadlo-Klarwasser G, Roth J, Goebeler M, Mahnke K, Falk M, Meinardus-Hager G, Sorg C
Abstract excerpt
Monocytes/macrophages expressing an epitope recognized by a monoclonal antibody 27E10 are present in acute but are absent in chronic inflammatory disorders. This report shows that the 27E10 antigen is formed by noncovalent association of the two Ca(2+)-binding proteins MRP8 and MRP14 which belong...
Topics
- Acute Disease
- Antibodies, Monoclonal
- Calcium-Binding Proteins
- Calgranulin A
- Calgranulin B
- Chronic Disease
- Epitopes
- Humans
- Inflammation
- Macrophages
- Monocytes
- Phenotype