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Phosphorylation and Rapid Relocalization of 53BP1 to Nuclear Foci upon DNA Damage

1 Mar 2001

Abstract excerpt

53BP1 is a human BRCT protein that was originally identified as a p53-interacting protein by the Saccharomyces cerevisiae two-hybrid screen. Although the carboxyl-terminal BRCT domain shows similarity to Crb2, a DNA damage checkpoint protein in fission yeast, there is no evidence so far that implicates 53BP1 in the checkpoint. We have identified a Xenopus homologue of 53BP1 (XL53BP1). XL53BP1 is associated with...

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Identifiers

PMID: 11238909
DOI: 10.1128/mcb.21.5.1719-1729.2001

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Phosphorylation and Rapid Relocalization of 53BP1 to Nuclear Foci upon DNA DamagePMID 11238909Read ↗

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