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Genetic dissection of vertebrate 53BP1: a major role in non-homologous end joining of DNA double strand breaks.

DNA repair - 10 Jun 2006

Nakamura Kyoko, Sakai Wataru, Kawamoto Takuo, Bree Ronan T, Lowndes Noel F, Takeda Shunichi, Taniguchi Yoshihito

Abstract excerpt

53BP1 (p53 binding protein) is a BRCT domain-containing protein that is rapidly recruited to DNA double strand breaks (DSBs). To investigate the role of 53BP1 in the DNA damage response, we generated 53BP1(-/-) cells from the chicken DT40 cell line. As in mammalian cells, mutation of 53BP1 increased cellular sensitivity to ionizing radiation. Although depletion of 53BP1 resulted in checkpoint defects in mammalian...

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Identifiers

PMID: 16644291
DOI: 10.1016/j.dnarep.2006.03.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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