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Article

Essential role of Gab1 for signaling by the c-Met receptor in vivo.

The Journal of cell biology - 18 Sept 2000

Sachs M, Brohmann H, Zechner D, Müller T, Hülsken J, Walther I, Schaeper U, Birchmeier C, Birchmeier W

Abstract excerpt

The docking protein Gab1 binds phosphorylated c-Met receptor tyrosine kinase directly and mediates signals of c-Met in cell culture. Gab1 is phosphorylated by c-Met and by other receptor and nonreceptor tyrosine kinases. Here, we report the functional analysis of Gab1 by targeted mutagenesis in t...

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Share to Proto-Oncogene Proteins c-met
Share to Adaptor Proteins, Signal Transducing
Share to Hepatocyte Growth Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to In Situ Hybridization

Share to Muscle Fibers, Skeletal

Share to Muscle, Skeletal

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Source

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Identifiers

PMID: 10995442
DOI: 10.1083/jcb.150.6.1375
PMCID: PMC2150711

Genes

HGF
IRS1
IRS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-10995442-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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