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Article

Threonine-17 phosphorylation of phospholamban: a key determinant of frequency-dependent increase of cardiac contractility.

Journal of molecular and cellular cardiology - 1 Aug 2004

Zhao Wen, Uehara Yoshiki, Chu Guoxiang, Song Qiujing, Qian Jiang, Young Karen, Kranias Evangelia G

Abstract excerpt

Multiple studies have shown that phospholamban (PLN) plays a key role in regulation of frequency-dependent increase of cardiac contraction, a hallmark of the contractile reserve in myocardium. However, the mechanisms underlying this relationship remain elusive. Phosphorylation of PLN occurs on residues: serine-16 (Ser(16)) and threonine-17 (Thr(17)) in vivo. In isolated wild-type cardiomyocytes, we found that...

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Identifiers

PMID: 15276030
DOI: 10.1016/j.yjmcc.2004.05.013

Genes

PLN
TTR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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